As a force of national economic and social development, micro, small and medium-sized enterprises (MSMEs) have suffered a severe impact on their business activities during the outbreak of COVID19. The business recovery of MSMEs is directly related to the income of residents as well as the overall stability of the social economy. Based on the analysis of the operating data of 5.6 million MSMEs, the Research Center for Intelligent Finance (THUIFR), found that from the beginning of March to the end of April 2020, MSMEs resumed their operation at relative rapid rate by virtue of their resilience. However, in May, the recovery of MSMEs entered a bottleneck period, and they urgently need the economic and financial support policies. In terms of size, small enterprises have not recovered as well as medium-sized enterprises and micro-enterprises. Regionally, most of the provinces and cities in the Yangtze River Basin and Hainan province have the lowest level of operational recovery, so it is necessary to focus on targeted support policies based on the differences of the locally affected industries.